Antibodies to factor VIII. V. Patterns of immune response to factor VIII in hemophilia A

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Antibodies to factor VIII. V. Patterns of immune response to factor VIII in hemophilia A.

The natural history of factor VIII antibodies was studied in 20 severe, multitransfused hemophiliacs. Two patterns of humoral immune reactivity were observed. In one group of ten, who developed antibodies after an average of 22 cumulative exposure days to factor VIII, the antibody titers increased after each antigenic stimulation or persisted for years in the absence of transfusion. These patie...

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Antibodies to Factor VIII . V . Patterns of Immune

The natural history of factor VIII antibodies VIII neutralizing activity appeared after a was studied in 20 severe, multitransfused longer exposure period (48 days). Antihemophiliacs. Two patterns of humoral body titers remained low, and there was immune reactivity were observed. In one no significant difference in individual titers group of ten, who developed antibodies before and 8-20 days fo...

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Antibodies to Factor VIII . V . Patterns

The natural history of factor VIII antibodies VIII neutralizing activity appeared after a was studied in 20 severe, multitransfused longer exposure period (48 days). Antihemophiliacs. Two patterns of humoral body titers remained low, and there was immune reactivity were observed. In one no significant difference in individual titers group of ten, who developed antibodies before and 8-20 days fo...

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FACTOR V AND VIII INHIBITOR IN PATIENTS WITH COMBINED FACTOR V AND VIII DEFICIENCY

Patients with coagulation factor(s) deficiency who use coagulation therapy are susceptible to forming inhibitors against coagulation factor(s). In this survey we detected factor V and VIII inhibitor in ten patients with combined deficiency of factors V and VIII from north east of Iran (Khorassan province). It was revealed in our survey that eight patients had both factor V and factor VIII i...

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Noncoagulation inhibitory factor VIII antibodies after induction of tolerance to factor VIII in hemophilia A patients.

We recently described tolerance induction with factor VIII/IX, cyclophosphamide, and high-dose intravenous IgG in hemophilia A or B patients with coagulation inhibitory antibodies. Circulating noninhibitory antibodies complexed with factor IX have been demonstrated in tolerant hemophilia B patients. Similar findings are now described in six tolerant hemophilia A patients. Complexes between fact...

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ژورنال

عنوان ژورنال: Blood

سال: 1976

ISSN: 0006-4971,1528-0020

DOI: 10.1182/blood.v47.6.973.973